As well as assessing the monthly fluctuation in Oestradiol and Progesterone through the female hormone panel, this panel also assesses the Melatonin and Adrenal Hormones, Cortisol and DHEA. The hormone Melatonin is the major neuroendocrine modulator of annual and circadian biorhythms in the body. Abnormalities of Melatonin circadian function have been closely linked to a variety of behavioural changes and mood disorders including: female hormone disturbance, insomnia, sleep-wake problems, mood disturbance, increased risk of cardiovascular disease, immune dysfunction, inhibition of ovulation and low body temperature.